Synthesis of carbon nanostructures using hydrothermal method and investigation of its application in drug release control

Heidary, Farhad; Farzinpour, Fatemeh Sadat

doi:10.61186/CNJ.2.1.214

Synthesis of carbon nanostructures using hydrothermal method and investigation of its application in drug release control

Document Type : Original Article

Authors

Farhad Heidary

Fatemeh Sadat Farzinpour

Department of Chemistry, Faculty of Science, Arak University, Arak 38156‑8‑8349, Iran

10.61186/CNJ.2.1.214

Abstract

The aim of this research is to achieve regular and controlled drug release. For this reason, improving and increasing the quality and ability of drug delivery systems has been of great interest. A very important issue in the drug delivery system is to achieve a stable and resistant formulation in such a way that it greatly increases the effectiveness of the drug in the target tissue by circulating and releasing the drug at a certain time. With this aim, biodegradable polymers are used due to their availability, biodegradability, easy manufacturing, and nanoparticles to control the rate of drug release into the body. In this research, the synthesis of carbon nanostructure was carried out using carrot juice extract by hydrothermal method, and the suitable temperature for synthesis was investigated. The results showed that heating for 24 hours at a temperature of 180 0C is suitable. Then, polymer nanocomposites consisting of chitosan, gelatin, carbon nanostructure and tetracycline drug were prepared. The results showed that nanostructures coated with polymer lead to better drug delivery performance. FTIR and XRD were used to characterize the prepared carbon nanostructure. The optimal samples containing 0.015 g of carbon nanostructure showed the best performance compared to other samples in drug release.

Keywords

Drug release

Polymer nanocomposite

Tetracycline

Chitosan

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